Facts About Cornelia de Lange Syndrome

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As with other syndromes, individuals with CdLS strongly resemble one another. Common characteristics include: low birthweight (often under five pounds), slow growth, small stature, and small head size. Typical facial features include thin eyebrows (which frequently meet at the midline), long eyelashes, a short upturned nose, and thin downturned lips. Other findings may include excessive body hair, small hands and feet, partial joining of the second and third toes, incurved fifth fingers, a cleft palate, and conditions such as gastroesophageal reflux, seizures,
feeding difficulties, eye problems, hearing loss, behavioral issues, and developmental delays. Limb differences, including missing limbs or portions of limbs (usually fingers, hands, or forearms) are also found in some individuals.

Source: Cornelia de Lange Syndrome Foundation